Sickle Cell
Normal < 170 cm/second
Conditional ≥ 170 cm/second, but < 200 cm/second
Abnormal ≥ 200 cm/second

Velocity criteria apply to all vessels within the circle of Willis.

1. Adams et al. Stroke Prevention Trial in Sickle Cell Anemia (STOP): Study Design. Controlled Clinical Trials. 1998;19:110-129.
2. Adams et al. Discontinuing Prophylactic Transfusions Used to Prevent Stroke in Sickle Cell Disease. The New England Journal of Medicine. 2005;353:2769-2778.
3. Lonergan et al. Sickle Cell Anemia. RadioGraphics. 2001;21:971-994.