Guideline No.	GRADE of recommendation	Level of evidence
8.1	2	B
We suggest venoactive drugs (diosmin, hesperidin, rutosides, sulodexide, micronized purified flavonoid fraction, or horse chestnut seed extract [aescin]) for patients with pain and swelling due to chronic venous disease, in countries where these drugs are available.
Guideline No.	GRADE of recommendation	Level of evidence
8.2	2	B
We suggest using pentoxifylline or micronized purified flavonoid fraction, if available, in combination with compression, to accelerate healing of venous ulcers.