6. We suggest laboratory evaluation for thrombophilia for patients with a history of recurrent venous thrombosis and chronic recurrent venous leg ulcers (Grade 2, Level C).
7. Laboratory evaluation for thrombophilia should include testing for inherited hypercoagulable factors (antithrombin deficiency, protein C and protein S deficiencies), factor V Leiden (resulting in activated protein C resistance), prothrombin G20210A, plasminogen activator inhibitor type 1 mutations, hyperhomocysteinemia, antiphospholipid antibodies (anticardiolipin and lupus anticoagulant), and cryoglobulins and cryoagglutinins.