1. We suggest a strategy of early thrombus removal in selected patients meeting the following criteria:
   1. a first episode of acute iliofemoral deep venous thrombosis
   2. symptoms <14 days in duration
   3. a low risk of bleeding
   4. ambulatory with good functional capacity and an acceptable life expectancy (Grade 2, Level C)
2. We recommend early thrombus removal strategies as the treatment of choice in patients with limbthreatening venous ischemia due to iliofemoral deep venous thrombosis with or without associated femoro-popliteal venous thrombosis (phlegmasia cerulea dolens) (Grade 1, Level A).
3. We recommend that patients with isolated femoropopliteal deep venous thrombosis be managed with conventional anticoagulation therapy because there is currently insufficient evidence to support early thrombus removal strategies in this patient population (Grade 1, Level C).