Antidepressant response rates are higher for depression of a moderate to severe nature. For mild or subsyndromal depressive symptoms a complete assessment, ongoing support and monitoring, psychosocial interventions and lifestyle modifications should be the first lines of treatment. This may avoid the side-effects of medication and establish etiological factors important to future assessment and management. Antidepressants are appropriate in cases of persistent mild depression, where there is a past history of more severe depression, or where other interventions have failed.
Conditions: Depression
Treatments: Antidepressant
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Sources
- Barbui C, Cipriani A, Patel V, Ayuso-Mateos JL, van Ommeren M. Efficacy of antidepressants and benzodiazepines in minor depression: systematic review and meta-analysis. Br J Psychiatry. 2011 Jan;198(1):11-6. (PubMed)
- Cuijpers P, van Straten A, van Oppen P, Andersson G. Are psychosocial and pharmacologic interventions equally effective in the treatment of adult depressive disorders? A meta-analysis of comparative studies. J Clin Pyschiatry. 2008 Nov;69(11):1675-85. (PubMed)
- Esposito E, Wang JL, Adair CE, Williams JV, Dobson K, Schopflocher D, et al. Frequency and adequacy of depression treatment in a Canadian population sample. Can J Psychiatry. 2007 Dec;52(12):780-789. (PubMed)
- Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, et al. Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA. 2010 Jan 6;303(1):47-53. (PubMed)
- Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT. Inital Severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS Med. 2008 Feb;5(2):e45. (PubMed)
- National Institute for Health and Care Excellence. Depression in adults: The treatment and management of depression in adults. 2009 Oct [cited 2015 May 1]. (NICE)
- National Institute for Health and Care Excellence. Depression in adults: evidence update. 2012 Apr 1 [cited 2015 May 1]. (NICE)