The use of NSAIDS, including cyclo-oxygenase type 2 (COX-2) inhibitors, for the pharmacological treatment of musculoskeletal pain can elevate blood pressure, make antihypertensive drugs less effective, cause fluid retention and worsen kidney function in these individuals. Other medication prescribed by a healthcare professional may be safer than and as effective as NSAIDs.
Conditions: Chronic Kidney Disease (CKD), Kidney Failure, Renal Failure, Hypertension, High Blood Pressure (HBP), Diabetes (DM)
Treatments: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Aspirin, Ibuprofen, Naproxen
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Sources
- Gooch K, Culleton BF, Manns BJ, et al. NSAID use and progression of chronic kidney disease. Am. J. Med. Mar 2007;120(3):280.e281-287. (PubMed)
- National Heart, Lung, and Blood Institute. [cited 2007]. (U.S): Department of Health and Human Services. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. 2004 Aug [cited 2014 Sep 23]. (PDF)
- National Kidney Foundation. KDOQI clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification. Am J Kidney Dis. 2002;39(2 Suppl 1):S1–266. (PubMed)
- Scottish Intercollegiate Guidelines Network (sponsored by NHS Quality Improvement Scotland). Management of chronic heart failure: A national clinical guideline. Edinburgh (UK): Scottish Intercollegiate Guidelines Network (SIGN); 2007 Feb [cited 2014 Sep 23]. (PDF)