Practical Tips
For patients >75 years of age, the FRS is not well validated Clinical judgement is required in consultation with the patient to determine the value of pharmacotherapy One approach is extrapolation of modified FRS – identifies most subjects as intermediate- to high-risk, based on age
Among individuals 30-59 years of age without diabetes, the presence of a positive history of premature CVD (men <55 and women <65 years of age in first-degree relatives) increases an individual's calculated Framingham percent risk by approximately 2-fold. The 10-year Framingham risk percent doubled for family history of premature CVD will be referred to as the modified FRS.