Overall risk/benefit ratio favours therapy in patients meeting criteria for lipid lowering therapy and cardiovascular risk reduction<ol type='1'><li>Despite concerns about a variety of other possible adverse effects, all purported statin-associated symptoms should be evaluated systematically, incorporating observation during cessation, reinitiation (same or different statin, same or lower potency, same or decreased frequency of dosing) to identify a tolerated, statin-based therapy for chronic use (Recommendation Strong, Quality Very Low)</li><li>Statins should not be withheld on the basis of a potential, small-risk of new-onset diabetes mellitus emerging during long-term therapy (Recommendation Strong, Quality Very Low)</li><li>Vitamins, minerals or supplements for symptoms of myalgia perceived to be statin-associated are not recommended (Recommendation Strong, Quality Very Low)</li></ul></li></ul>