Table 30: Cardiac hypertrophy including hypertrophic cardiomyopathy versus restrictive cardiomyopathy
	Cardiac hypertrophy	Restrictive cardiomyopathy
Prevalence	High	Low
Onset	Late	Early
Gender	Female > male	Male = female
Family history	Uncommon except in HCM	≈ 30%
Hypertension	Common	Uncommon
Obesity	Common	Uncommon
Hypertrophy	Moderate/Marked	None/mild
Echocardiographic/MRI findings	Diastolic dysfunction grade 1-2, mild left atrial enlargement, usually preserved ejection fraction	Diastolic dysfunction grade 3, severe biatrial enlargement, preserved ejection fraction
Hemodynamics	Elevated left ventricular end-diastolic pressure	Steep “Y” descent, dip and plateau pattern
Coronary heart disease	Common co-morbid condition	Uncommon
Natriuretic peptide	Variable	Elevated
Endomyocardial biopsy	Non-specific	Specific findings