| Lecoq et al. |
|---|
| Definition of CRT response |
| Alive, no HF readmission, > 1 NYHA class improvement (or > 10% increase in peak VO2 and 6MW) |
| Follow-up (months) |
| 6 |
| Predictors of CRT response |
| QRS shortening during CRT |
| Achilli et al. |
| Definition of CRT response |
| Improved clinical composite score and LVEF increase ≥ 5% |
| Follow-up (months) |
| 6 |
| Predictors of CRT response |
| Smaller LVESD, longer interventricular mechanical delay |
| MIRACLE/MIRACLE ICD |
| Definition of CRT response |
| Alive and > 1 NYHA class improvement |
| Follow-up (months) |
| 1, 3, and 6 |
| Predictors of CRT response |
| None |
| Yeim et al. |
| Definition of CRT response |
| > 1 NYHA class improvement and no HF admission |
| Follow-up (months) |
| 6 |
| Predictors of CRT response |
| Nonischemic etiology, wider baseline QRS width, QRS shortening during |
| Mollema et al. |
| Definition of CRT response |
| ≥ 1 NYHA class improvement or 10% decrease in LVESV |
| Follow-up (months) |
| 6 |
| Predictors of CRT response |
| None |
| PROSPECT |
| Definition of CRT response |
| Improved clinical composite score and LVESV decrease ≥ 15% |
| Follow-up (months) |
| 6 |
| Predictors of CRT response |
| None |
| Buck et al. |
| Definition of CRT response |
| LVESV decrease > 10% |
| Follow-up (months) |
| 6 |
| Predictors of CRT response |
| Interlead distance > 127 mm, septal-lateral delay > 60 ms, nonischemic etiology, LV end-diastolic diameter < 67 mm, use of ACE inhibitor, absence of tricuspid regurgitation |
| Rickard et al. |
| Definition of CRT response |
| LVESV decrease ≥ 10% |
| Follow-up (months) |
| > 2 |
| Predictors of CRT response |
| Wider QRS |
| MADIT-CRT |
| Definition of CRT response |
| % decrease in LVEDV and response score |
| Follow-up (months) |
| 12 |
| Predictors of CRT response |
| Female, nonischemic etiology, LBBB, QRS > 150 ms, previous HF hospitalization, LVEDV > 125 mL/m2, left atrial volume < 40 mL/m2 |
| PROSPECT-ECG |
| Definition of CRT response |
| Improved clinical composite score, LVESV decrease 15% |
| Follow-up (months) |
| 6 |
| Predictors of CRT response |
| LBBB morphology, LV paced QRS width and QRS shortening |
ACE, angiotensin-converting enzyme; CRT, cardiac resynchronization therapy; HF, heart failure; LBBB, left bundle branch block; LV, left ventricular; LVEF, LV ejection fraction; LVEDV, LV end-diastolic volume; LVESD, LV end-systolic dimension; LVESV, LV end-systolic volume; MADIT-CRT, Multicenter Automatic Defibrillator Implantation Trial - Cardiac Resynchronization Therapy; MIRACLE, Multicenter InSync Randomized Clinical Evaluation; MIRACLE ICD, Mulitcenter Insync ICD Randomized Clinical Evaluation; 6MW, 6-minute walk; NYHA, New York Heart Association; PROSPECT, Predictors of Response to Cardiac Resynchronization Therapy; PROSPECT-ECG, Predictors of Response to Cardiac Resynchronization Therapy ECG. Modified from Ellenbogen et al.13 with permission from Elsevier