We recommend intermittent antiarrhythmic drug therapy ("pill in the pocket") in symptomatic patients with infrequent, longer-lasting episodes of AF or AFL as an alternative to daily antiarrhythmic therapy. (Recommendation Strong, Quality Moderate)<br /><br /><b>Values and preferences: </b>This recommendation places a high value on the results of clinical studies demonstrating the efficacy and safety of intermittent antiarrhythmic drug therapy in selected patients.