| Strength of a Recommendation |
| Strong: | Benefits do (or do not) outweigh risks and burdens |
| Conditional: | Benefits and risks are finely balanced, or appreciable uncertainty exists about the magnitude of benefits and risks. Additionally, fully informed patients are liable to make different choices. |
| Quality of Evidence |
| High: | Further research is very unlikely to change our confidence in the estimate of effect. |
| Moderate: | Futher research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. |
| Low: | Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. |
| Very Low: | Any estimate is very uncertain. |