Peak mitral velocity ≥1.9 m/s*
Sensitivity: 90%
Specificity: 89%
Comments: Also consider high flow, PPM
VTIPrMV/VTILVO ≥ 2.5*
Sensitivity: 89%
Specificity: 91%
Comments: Measurement errors increase in atrial fibrillation due to difficulty in matching cardiac cycles; also consider PPM
Mean gradient ≥ 5 mmHg*
Sensitivity: 90%
Specificity: 70%
Comments: At physiologic heart rates; also consider high flow, PPM
Maximal TR jet velocity > 3 m/s*
Sensitivity: 80%
Specificity: 71%
Comments: Consider residual postoperative pulmonary hypertension or other causes
LV stroke volume derived by 2D or 3D imaging is >30% higher than systemic stroke volume by Doppler
Sensitivity: Moderate sensitivity
Specificity: Specific
Comments: Validation lacking; significant MR is suspected when LV function is normal or hyperdynamic and VTILVO is <16 cm
Systolic flow convergence seen in the left ventricle toward the prosthesis
Sensitivity: Low sensitivity
Specificity: Specific
Comments: Validation lacking; technically challenging to detect readily

PrMV, Prosthetic mitral valve.
*Data from Olmos et al. When both peak velocity and VTI ratio are elevated with a normal pressure half-time, specificity is close to 100%.